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Tofranil (generic name: Imipramine; brand names include: Antideprin / Deprenil / Deprimin / Deprinol / Depsonil / Dynaprin / Eupramin / Imipramil / Irmin / Janimine / Melipramin / Surplix / Antidep / Apo-Imipramine / Chrytemin / Daypress / Depsol / Ethipramine / Fronil / Imidol / Imimine / Imine / Imiprex / Imiprin / Impril / Medipramine / Melipramine / Mipralin / Novopramine / Primonil / Pryleugan / Sermonil / Sipramine / Talpramin / Tofnil / Tofranil-PM / Venefon) belongs to a group of medicines known as tricyclic antidepressants.
Tofranil is used for the treatment of depression including endogenous, organic and psychogenic forms, and depression associated with personality disorders or chronic alcoholism.
Tofranil may also be used to treat bedwetting (enuresis) in children (5 years and older).
Follow the directions for using this medicine provided by your doctor. Take Tofranil exactly as directed.
Depression and depressive syndromes
Adults
Start treatment with 25 mg 1-3 times daily. Raise the daily dosage gradually to 150-200 mg. This dosage should be reached by the end of the first week and maintained to this dose until a clear improvement is seen. The maintenance dose, which must be individually determined by cautiously reducing the dosage, is usually 50-100 mg daily.
Elderly patients
Start treatment with 1 tablet of 10 mg daily. Gradually raise the dosage to 30-50 mg daily (optimum level), which should be reached after about 10 days and then maintained until the end of treatment.
Childhood Enuresis
Initially, an oral dose of 25 mg/day should be tried in children aged 5 and older. Medication should be given one hour before bedtime. If a satisfactory response does not occur within one week, increase the dose to 50 mg nightly in children under 12 years; children over 12 may receive up to 75 mg nightly. A daily dose greater than 75 mg does not enhance efficacy and tends to increase side effects. Evidence suggests that in early night bedwetters, the drug is more effective given earlier and in divided amounts, i.e., 25 mg in midafternoon, repeated at bedtime. Consideration should be given to instituting a drug-free period following an adequate therapeutic trial with a favorable response. Dosage should be tapered off gradually rather than abruptly discontinued.
Tell your doctor before taking Tofranil, if:
you are allergic to any medicines;
you have any serious medical conditions;
you are pregnant or breast-feeding.
Active ingredient: imipramine.
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Naomi Steuard, MA:
I have been using Tofranil for about three months to treat my panic disorder. I had suffered with panic attacks since I was around 23 years old after I had a nervous breakdown. My doctor prescribed me with a number of medications, but I have found the perfect on only when he put me on Tofranil. Within as little as weeks I was able to not only get out of my house without fear but also to go shopping and visit friends. It takes time to adapt, but without Tofranil I would have had almost no freedom and mobility now. The only side effect I experienced was minor sleepiness. But for me that was nothing to getting my life back.
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Sandra Perkins, Chicago:
I suffered from depression since I was a teenager. Sometimes the disease used to make me completely immobile and devastated. Our family doctor prescribed me with several drugs without any success. Then we decided to try Tofranil because some of his other patients showed considerable improvements after switching to this medication. After a few days on Tofranil I noticed gradual improvement in my condition which lasted for about 1 month. Since that time I haven't had a single period of depression. So if you plan to start Tofranil treatment, get ready for good sleep at night, increased appetite and feeling of harmony. I remember when after a week on Tofranil I went outside one day and it seemed as if I first noticed how beautiful the world around me was.
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Priscilla Watkins, Toronto:
I have suffered with panic attacks all my life since I was undiagnosed about 20 years ago. I am now 34 and I have tried almost every medication available on the market. I have been to hospital for several times but ambulatory treatment produced temporary effect only. When I started having other health problems after using strong medications I decided to try Tofranil as the last escape. Before that I was having constant panic attacks and after switching to Tofranil they disappeared. I have minor attacks sometimes when I miss a dose. I'm absolutely satisfied with the way this medication works as I haven't noticed any side effects with it.
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Nigel Fox, Wichita:
I had night panic attacks for over 4 years or more after I got into a car accident where many people died and still more were injured. I had almost lost hope to find a medication that would get me rid of these nightmares. After the first dose of Tofranil, I slept normal without waking up till the morning and it was like a gulp of fresh air. It's been now more than seven years since I started on Tofranil without changing my medication and it is working without any alterations. I am so thankful to have finely found this medicine that actually works for me and causes no side effects.